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Six of the peptides were among those the agency raised safety concerns about in 2023

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(7) Linkova N, Khavinson V, Diatlova A, Petukhov M, Vladimirova E, Sukhareva M, Ilina A

this correlation may be attributed to the additional intestinal gas in patients with SIBO, causing an increase in intra-abdominal pressure, which could lead to a large reflux of gastric contents into the esophagus (Takakura and Pimentel, 2020)